Under Construction

2020

2022

UNDER CONSTRUCTION

​2020-2021

UNDER CONSTRUCTION

Simón J, Goikoetxea-Usandizaga N, Serrano-Maciá M, Fernández-Ramos D, Sáenz de Urturi D, Gruskos JJ, Fernández-Tussy P, Lachiondo-Ortega S, González-Recio I, Rodríguez-Agudo R, Gutiérrez-de-Juan V, Rodríguez-Iruretagoyena B, Varela-Rey M, Gimenez-Mascarell P, Mercado-Gomez M, Gómez-Santos B, Fernandez-Rodriguez C, Lopitz-Otsoa F, Bizkarguenaga M, Dames S, Schaeper U, Martin F, Sabio G, Iruzubieta P, Crespo J, Aspichueta P, Chu KH, Buccella D, Martín C, Delgado TC, Martínez-Cruz LA, Martínez-Chantar ML. Magnesium accumulation upon cyclin M4 silencing activates microsomal triglyceride transfer protein improving NASH. J Hepatol. 2021 Feb 8:S0168-8278(21)00094-5. doi: 10.1016/j.jhep.2021.01.043. Epub ahead of print. PMID: 33571553.

https://www.journal-of-hepatology.eu/article/S0168-8278(21)00094-5/fulltext

Lenza MP, Oyenarte I, Diercks T, Quintana JI, Gimeno A, Coelho H, Diniz A, Peccati F, Delgado S, Bosch A, Valle M, Millet O, Abrescia NGA, Palazón A, Marcelo F, Jiménez-Osés G, Jiménez-Barbero J, Ardá A, Ereño-Orbea J. Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins. Angew Chem Int Ed Engl. 2020 Dec 21;59(52):23763-23771. doi: 10.1002/anie.202011015. Epub 2020 Oct 22. PMID: 32915505.

https://onlinelibrary.wiley.com/doi/10.1002/anie.202011015

Martínez JD, Manzano AI, Calviño E, Diego A, Rodriguez de Francisco B, Romanò C, Oscarson S, Millet O, Gabius HJ, Jiménez-Barbero J, Cañada FJ. Fluorinated Carbohydrates as Lectin Ligands: Simultaneous Screening of a Monosaccharide Library and Chemical Mapping by 19F NMR Spectroscopy. J Org Chem. 2020 Dec 18;85(24):16072-16081. doi: 10.1021/acs.joc.0c01830. Epub 2020 Dec 1. PMID: 33258593; PMCID: PMC7773211.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773211/

Bernardo-Seisdedos G, Bilbao J, Fernández-Ramos D, Lopitz-Otsoa F, Gutierrez de Juan V, Bizkarguenaga M, Mateos B, Fondevila MF, Abril-Fornaguera J, Diercks T, Lu SC, Nogueiras R, Mato JM, Millet O. Metabolic landscape of the mouse liver by quantitative 31 P-NMR analysis of the phosphorome.

Hepatology. 2020 Dec 7. doi: 10.1002/hep.31676. Epub ahead of print. PMID: 33284502.

https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.31676

Mercado-Gómez M, Lopitz-Otsoa F, Azkargorta M, Serrano-Maciá M, Lachiondo-Ortega S, Goikoetxea-Usandizaga N, Rodríguez-Agudo R, Fernández-Ramos D, Bizkarguenaga M, Juan VG, Lectez B, Aloria K, Arizmendi JM, Simon J, Alonso C, Lozano JJ, Avila MA, Banales JM, Marin JJG, Beraza N, Mato JM, Elortza F, Barrio R, Sutherland JD, Mayor U, Martínez-Chantar ML, Delgado TC. Multi-Omics Integration Highlights the Role of Ubiquitination in CCl4-Induced Liver Fibrosis.Int J Mol Sci. 2020 Nov 27;21(23):9043. doi: 10.3390/ijms21239043. PMID: 33261190; PMCID: PMC7729774.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7729774/

Li Y, Lu L, Tu J, Zhang J, Xiong T, Fan W, Wang J, Li M, Chen Y, Steggerda J, Peng H, Chen Y, Li TWH, Zhou ZG, Mato JM, Seki E, Liu T, Yang H, Lu SC. Reciprocal Regulation Between Forkhead Box M1/NF-κB and Methionine Adenosyltransferase 1A Drives Liver Cancer. Hepatology. 2020 Nov;72(5):1682-1700. doi: 10.1002/hep.31196. Epub 2020 Oct 1. PMID: 32080887; PMCID: PMC7442711.

https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.31196

Kilanczyk E, Banales JM, Wunsch E, Barbier O, Avila MA, Mato JM, Milkiewicz M, Milkiewicz P. S-adenosyl-L-methionine (SAMe) halts the autoimmune response in patients with primary biliary cholangitis (PBC) via antioxidant and S-glutathionylation processes in cholangiocytes. Biochim Biophys Acta Mol Basis Dis. 2020 Nov 1;1866(11):165895. doi: 10.1016/j.bbadis.2020.165895. Epub 2020 Jul 16. PMID: 32681864.

Bertuzzi S, Gimeno A, Núñez-Franco R, Bernardo-Seisdedos G, Delgado S, Jiménez-Osés G, Millet O, Jiménez-Barbero J, Ardá A. Unravelling the Time Scale of Conformational Plasticity and Allostery in Glycan Recognition by Human Galectin-1. Chemistry. 2020 Dec 1;26(67):15643-15653. doi: 10.1002/chem.202003212. Epub 2020 Oct 29. PMID: 32780906; PMCID: PMC7756784.

Unione L, Ardá A, Jiménez-Barbero J, Millet O. NMR of glycoproteins: profiling, structure, conformation and interactions. Curr Opin Struct Biol. 2020 Oct 28;68:9-17. doi: 10.1016/j.sbi.2020.09.009. Epub ahead of print. PMID: 33129067.

Bruzzone C, Bizkarguenaga M, Gil-Redondo R, Diercks T, Arana E, García de Vicuña A, Seco M, Bosch A, Palazón A, San Juan I, Laín A, Gil-Martínez J, Bernardo-Seisdedos G, Fernández-Ramos D, Lopitz-Otsoa F, Embade N, Lu S, Mato JM, Millet O. SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum.

iScience. 2020 Oct 23;23(10):101645. doi:10.1016/j.isci.2020.101645. Epub 2020 Oct 5. PMID: 33043283; PMCID: PMC7534591.

 

Robinson AE, Binek A, Venkatraman V, Searle BC, Holewinski RJ, Rosenberger G, Parker SJ, Basisty N, Xie X, Lund PJ, Saxena G, Mato JM, Garcia BA, Schilling B, Lu SC, Van Eyk JE. Lysine and Arginine Protein Post-translational Modifications by Enhanced DIA Libraries: Quantification in Murine Liver Disease.J Proteome Res. 2020 Oct 2;19(10):4163-4178. doi: 10.1021/acs.jproteome.0c00685. Epub 2020 Sep 23. PMID: 32966080.

Fernández-Ramos D, Lopitz-Otsoa F, Delacruz-Villar L, Bilbao J, Pagano M, Mosca L, Bizkarguenaga M, Serrano-Macia M, Azkargorta M, Iruarrizaga-Lejarreta M, Sot J, Tsvirkun D, van Liempd SM, Goni FM, Alonso C, Martínez-Chantar ML, Elortza F, Hayardeny L, Lu SC, Mato JM. Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis. AMPK and mTOR regulation. World J Gastroenterol. 2020 Sep 14;26(34):5101-5117. doi: 10.3748/wjg.v26.i34.5101. PMID: 32982112; PMCID: PMC7495035.


San Juan I, Bruzzone C, Bizkarguenaga M, Bernardo-Seisdedos G, Laín A, Gil-Redondo R, Diercks T, Gil-Martínez J, Urquiza P, Arana E, Seco M, García de Vicuña A, Embade N, Mato JM, Millet O. Abnormal concentration of porphyrins in serum from COVID-19 patients. Br J Haematol. 2020 Sep;190(5):e265-e267. doi: 10.1111/bjh.17060. Epub 2020 Aug 29. PMID: 32745239; PMCID: PMC7436216.

 

Millet O, Cortajarena AL, Salvatella X, Kiessling LL, Jiménez-Barbero J. Scientific Response to the Coronavirus Crisis in Spain: Collaboration and Multidisciplinarity. ACS Chem Biol. 2020 Jul 17;15(7):1722-1723. doi: 10.1021/acschembio.0c00496. Epub 2020 Jun 25. PMID: 32584537; PMCID: PMC7323048.

 

Fernández-Hernández P, Sánchez-Calabuig MJ, García-Marín LJ, Bragado MJ, Gutiérrez-Adán A, Millet Ó, Bruzzone C, González-Fernández L, Macías-García B. Study of the Metabolomics of Equine Preovulatory Follicular Fluid: A Way to Improve Current In Vitro Maturation Media. Animals (Basel). 2020 May 19;10(5):883. doi: 10.3390/ani10050883. PMID: 32438699; PMCID: PMC7278476.


Bruzzone C, Loizaga-Iriarte A, Sánchez-Mosquera P, Gil-Redondo R, Astobiza I, Diercks T, Cortazar AR, Ugalde-Olano A, Schäfer H, Blanco FJ, Unda M, Cannet C, Spraul M, Mato JM, Embade N, Carracedo A, Millet O. H NMR-Based Urine Metabolomics Reveals Signs of Enhanced Carbon and Nitrogen Recycling in Prostate Cancer.

J Proteome Res. 2020 Jun 5;19(6):2419-2428. doi: 10.1021/acs.jproteome.0c00091. Epub 2020 May 18. PMID: 32380831.

Fondevila MF, Fernandez U, Gonzalez-Rellan MJ, Da Silva Lima N, Buque X, Gonzalez-Rodriguez A, Alonso C, Iruarrizaga-Lejarreta M, Delgado TC, Varela-Rey M, Senra A, Garcia-Outeiral V, Novoa E, Iglesias C, Porteiro B, Beiroa D, Folgueira C, Tojo M, Torres JL, Hernández-Cosido L, Blanco Ó, Arab JP, Barrera F, Guallar D, Fidalgo M, López M, Dieguez C, Marcos M, Martinez-Chantar ML, Arrese M, Garcia-Monzon C, Mato JM, Aspichueta P, Nogueiras R. The L-α-Lysophosphatidylinositol/G Protein-Coupled Receptor 55 System Induces the
Development of Nonalcoholic Steatosis and Steatohepatitis. Hepatology. 2020 Apr23. doi: 10.1002/hep.31290. Epub ahead of print. PMID: 32329085.

Simon J, Nuñez-García M, Fernández-Tussy P, Barbier-Torres L, Fernández- Ramos D, Gómez-Santos B, Buqué X, Lopitz-Otsoa F, Goikoetxea-Usandizaga N, Serrano-Macia M, Rodriguez-Agudo R, Bizkarguenaga M, Zubiete-Franco I, Gutiérrez-de Juan V, Cabrera D, Alonso C, Iruzubieta P, Romero-Gomez M, van Liempd S, Castro A, Nogueiras R, Varela-Rey M, Falcón-Pérez JM, Villa E, Crespo J, Lu SC, Mato JM, Aspichueta P, Delgado TC, Martínez-Chantar ML. Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly. Cell Metab. 2020 Mar 3;31(3):605-622.e10. doi: 10.1016/j.cmet.2020.01.013. Epub 2020 Feb 21. PMID:32084378; PMCID: PMC7259377.

Noureddin M, Sander-Struckmeier S, Mato JM. Early treatment efficacy of S-adenosylmethionine in patients with intrahepatic cholestasis: A systematic review.World J Hepatol. 2020 Feb 27;12(2):46-63. doi: 10.4254/wjh.v12.i2.46. PMID: 32184941; PMCID: PMC7061266.