El metabolismo es el conjunto de reacciones bioquímicas y procesos fisicoquímicos que ocurren en una célula y en el organismo y el análisis del metabolismo puede permitir distinguir entre personas enfermas y sanas. Este video resume dos artículos científicos publicados en iScience y British Journal Hematology donde se llevó a cabo el análisis de una cohorte muy grande de pacientes COVID positivos en el estado agudo de la enfermedad mediante resonancia magnética nuclear, comparándolo con una cohorte de pacientes sanos. Los resultados de estos dos estudios demostraron la existencia de importantes cambios en el perfil metabólico y lipídico de los pacientes COVID y esto está relacionado con alteraciones en el hígado y un aumento en el riesgo de desarrollar enfermedades cardiovasculares. Por otro lado, ya se conocía la presencia de anemia hemolítica en pacientes COVID. Pudimos confirmar que gran parte de los pacientes padecía una ruta metabólica del grupo HEMO alterada. Se observó que muchos de los enfermos tienen los intermedios de esta ruta desregulados. En este momento se están analizando sueros de pacientes recuperados con el objetivo de ver cómo el metabolismo evoluciona y si vuelve a su estado normal. Articulo iScience: https://www.cell.com/iscience/fulltext/S2589-0042(20)30837-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589004220308373%3Fshowall%3Dtrue Articulo British Journal Haematology: https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.17060 Track: Evening Walk — Amine Maxwell [Audio Library Release] Music provided by Audio Library Plus Watch: https://youtu.be/PbvXvSzaJU4 Free Download / Stream: https://alplus.io/evening-walk

Prof. José M. Mato, Founder and Director of the CIC bioGUNE Center for Cooperative Research in Biosciences, Prof. Jesús Jiménez-Barbero, Scientific Director, and Dr. Óscar Millet, Principal Investigator, describe how the work of the center is helping to shape the future of healthcare, from diagnostics to precision medicine. Hear how high-throughput NMR methodology is essential in large-scale metabolomic studies to advance understanding of diseases such as liver disease, cancer and metabolic syndrome. For research use only.

Jornada de Terapia Génica en el instituto Biocruces. Hospital Universitario de Cruces. julio 2015. Conferencia de Oscar Millet. Investigador del CIC-Biogune.

The objectives of the laboratory of protein stability and hereditary diseases are to try to investigate the mechanisms of protein stability in pathologies, find new therapies against rare diseases, especially porphyria, and also obtain new biomarkers using NMR spectroscopy for search and quantification of metabolites. The metabolites change due to multiple sources, most of which are not pathogenic, and the sources of variability of a metabolite can be multiple. Therefore, understanding what concentrations are normal and what concentrations are abnormal is essential to properly and robustly identify biomarkers. #DropsofsciencebioGUNE https://www.cicbiogune.es/people/omillet

My particular interest is about metabolic liver disease, and in particular NASH. The liver is where most reactions take place. The liver has a function that is to take fatty acids from adipose tissue that are transported to the liver and the liver accumulates them and then it release the exact amount. If the amount is very large it ends in a cardiovascular problem. If it is very small, the organism does not reach enough. In 5 years we will begin to have data on which people need to worry, and which people do not need to worry about developing NASH. #DropsofsciencebioGUNE https://www.cicbiogune.es/people/jmmato